The Ultimate Guide to CBG (Cannabigerol)

What Is CBG?

CBD and THC have each taken center stage for quite some time. You can read more about those cannabinoids here.

But there’s a new kid in town that deserves some recognition (though, not new, just lesser-known). CBG is gaining some attention due to a growing body of evidence showing its potential value for various health applications. We’ll get to those later! So what exactly is CBG?

Let’s get the technical jargon out of the way.

Cannabigerol (CBG) is a cannabinoid that is naturally present in the cannabis plant.

CBGA, which is the acidic form of CBG, converts into one of three major cannabinoid precursors as the plant ages. These are: cannabidiolic acid (CBDA), tetrahydrocannabinolic acid (THCA), and cannabichromenic acid (CBCA). The CBGA that doesn’t get converted into one of the above or any other secondary cannabinoids will form CBG through decarboxylation. This chemical reaction removes one carbon atom from the acid molecule and activates the compounds in cannabis.

Does CBG Get You High?

No. Like CBD, CBG is one of over 100 cannabinoids in cannabis and is non-psychoactive – meaning it doesn’t produce any of the “high” sensations that are typically associated with marijuana.

Cannabis strains generally contain minuscule amounts of CBG, so special growers have begun experimenting with genetic manipulation so more people can benefit from the potential health advantages.

Many people get confused between CBD and CBG – and though the abbreviations are similar, they’re very different.

CBD vs CBG: What Is The Difference?

These two cannabinoids are often compared because they both affect your endocannabinoid system in a non-psychoactive way. They both are even touted as great aids in reducing the adverse effects of THC.

But what makes them different from each other?

Scientifically, their molecular structures are entirely different. The molecules have different shapes altogether and therefore bind to your body’s cannabinoid receptors in different ways. CBD prefers to activate the 5-HT1A receptor in the body, while CBG acts as an antagonist and blocks the same receptor. This difference makes their effects on the body distinctive as well.

CBG is also found in much less of a quantity in cannabis. The plant generally contains less than 1%, while CBD can make up 25%. So while the benefits of CBG tend to be very promising, the inclusion of it as an ingredient can make for an expensive product. (The good news is, TribeTokes CBD vape oils are full-spectrum – which means they actually contain 10% CBG as well as a host of other beneficial cannabinoids and terpenes!)

Together, the two cannabinoids make a great team and combine forces to create a potent anti-inflammatory. We know the potential benefits of CBD alone, like pain relief and help with insomnia, but what else can CBG do for you? Read on.

The Potential Benefits Of CBG

CBG has a variety of potential health benefits that expert medical researchers have studied. In many promising animal studies, the cannabinoid has been found to help with:

• Pain Reduction: Much like CBD, CBG is touted to help with inflammation and decrease pain.
• Inflammatory Bowel Disease: In studies of mice, CBG reduced inflammation and the formation of reactive oxygen species (ROS) in the intestines. ROS are considered unstable molecules that can cause damage to your DNA and kill cells.
• Glaucoma: Researchers studying cats have found that eye pressure decreased with CBG administration.
• Appetite Stimulation: preclinical studies have shown CBG to increase appetite in rats, which can be significant as a future treatment option for diseases and syndromes that may benefit from increased hunger.
• Huntington’s Disease: In a 2015 study, CBG was administered to mice with a form of Huntington’s Disease – which is a condition that breaks down nerve cells in the brain. CBG acted as a neuroprotectant.
• Anxiety: Not only does CBG mitigate some of the THC side effects, but much like CBD, it has a calming effect.
• Antibacterial Needs: A more recent study in 2020 showed that CBG has antibacterial properties, allowing it to fight against drug-resistant bacteria that cause staph infections.
• Bladder Dysfunctions: A 2015 study showed CBG to be the top cannabinoid contender when fighting bladder issues by positively affecting the bladder’s contractions.
• Skincare: CBG is rich in antioxidants, which can fight free radicals and help reduce the look of aging. And since it also has antibacterial properties, it may also help reduce acne and other skin inflammations that may result from bacteria.

The great news about CBG is that despite not having many clinical trials on humans to mimic the animals’ benefits, the adverse side effects are few and far between. Like with CBD, it’s best to avoid CBG if you take a medication with a grapefruit warning. Grapefruits contain chemicals called furanocoumarins, which disrupt the proteins that break down certain medications. These medicines will often come with a grapefruit warning. CBD binds with the same enzymes, and it’s likely that CBG may as well.

Where Can I Buy Products With CBG?

Since CBG is such a small part of the cannabis plant, products you’ll find will usually contain other cannabinoids, like CBD as well.

CBG Isolate exists (and is typically pretty expensive), but it doesn’t include the other cannabinoids, which isn’t necessarily a good thing. When you combine CBG with other cannabinoids and terpenes, you get what’s called the entourage effect.

The entourage effect makes the therapeutic benefits stronger because the CBG combined with other compounds, like terpenes, flavonoids, and other lesser-known cannabinoids.

The best way to get a dose of CBG is to purchase full-spectrum CBD products like these that are natural and contain no harmful additives.

Here are some product recommendations that will give you a clean, full-spectrum experience and contains both CBD and CBG:

• CBD Oil Vape Pen Starter Kit (includes battery and cartridge)
• CBD Disposable Vape Pens
• Full Gram CBD Cartridges

Just getting started with CBD vaping? Here’s some more information: Vaporizing Oils: Your 2021 Guide to CBD Vapes

Frequently Asked Questions

What is Indica, and what effects does it have on the body?

Indica is a variation of Cannabis sativa that is renowned for producing a calming and soothing effect on the body. This is why it is often used to manage stress, anxiety, and pain.

The primary reason for Indica’s sedative effect is its high levels of cannabidiol (CBD) and tetrahydrocannabinol (THC), which interact with the body’s endocannabinoid system to produce therapeutic benefits. CBD is known for its relaxing properties, while THC is the cause of the “high” commonly associated with cannabis use.

Indica strains help promote sleep and relaxation and manage various medical conditions, including chronic pain, headaches, muscle spasms, seizures, and more. They are also often used to treat anxiety and depression and manage multiple sclerosis symptoms and other neurological issues.

When consumed, Indica strains produce a strong body high that is often described as relaxing and sleep-inducing. This can result in feelings of euphoria, an improved sense of well-being, reduced muscle tension and pain, increased appetite, and reduced nausea.

While Indica strains are typically safe and well-tolerated, it is vital to use them cautiously and in moderation. Overuse can lead to adverse side effects such as dry mouth, dry eyes, dizziness, and coordination difficulties. It is also essential to be aware of any potential interactions with other medications and to consult a doctor before using Indica strains for medical purposes.

What causes Indica to make a person feel sleepy?

The reputation of Indica strains of Cannabis sativa is based on their ability to induce relaxation and sedation, often leading to sleepiness. This is due to the presence of CBD and THC, two primary compounds found in Indica strains.

CBD is known for its calming and soothing properties, which is why it is frequently used to relieve anxiety, stress, and pain. CBD interacts with the endocannabinoid system when ingested, which regulates mood, sleep, and pain perception. This interaction creates a relaxing and calming effect, increasing feelings of well-being and reducing stress and anxiety.

THC, on the other hand, is the compound that causes the “high” experienced with cannabis use. It is a psychoactive substance that attaches to cannabinoid receptors in the brain, leading to euphoria and relaxation. Although THC can produce a sedative effect, the most effective way of promoting sleep and relaxation is through THC and CBD.

When taken, Indica strains result in a potent body high that is often described as relaxing and sedative. This can result in euphoria, reduced muscle tension and pain, increased appetite, and decreased nausea. These effects collectively contribute to the feeling of sleepiness that many users report after consuming Indica strains.

It is important to consider that the effects of Indica strains can vary significantly based on factors such as the specific strain, dose, and individual tolerance. 

Is Indica the only strain of cannabis that causes sleepiness?

Contrary to popular belief, Indica is not the only type of cannabis that can result in drowsiness. While Indica is recognized for its calming and sleep-inducing effects, other strains of cannabis can also have similar effects.

Cannabis strains are usually divided into three main categories: Indica, Sativa, and Hybrid. Indica is known for its sedating effects, while Sativa is associated with its energetic and uplifting effects. Hybrid strains, as the name suggests, combine Indica and Sativa and can have effects that fall somewhere in between.

The effects of a particular strain of cannabis are determined by its chemical composition, particularly the ratio of CBD to THC. CBD is recognized for its calming properties, while THC is responsible for the psychoactive “high” effect. Cannabis strains with higher levels of CBD tend to have more sedating effects, while strains with higher levels of THC tend to be more euphoric and energetic.

For instance, some Sativa strains can have high CBD and low THC levels, resulting in relaxing effects similar to Indica strains. On the other hand, some Indica strains can have low CBD and high THC levels, leading to more energetic and invigorating effects.

Can Indica be used to treat insomnia and sleep disorders?

Indica strains of Cannabis sativa have a reputation for promoting relaxation and inducing sleep, making them a potential option for treating insomnia and sleep disorders. However, the effectiveness of Indica for such purposes remains a subject of ongoing scientific study and debate.

Limited evidence indicates that cannabis use may help alleviate sleep problems in specific populations, such as those with chronic pain or post-traumatic stress disorder. However, more research is needed to see the impact of Indica and other cannabis strains on sleep.

Moreover, the suitability of cannabis use may vary, particularly for individuals with a history of substance abuse or mental health conditions. Additionally, the potency and quality of cannabis can significantly impact its effectiveness as a sleep aid, and the method of consumption (such as smoking, edibles, or tinctures) can affect the timing and duration of its effects.

Are there any potential negative side effects of using Indica before bedtime?

There are potential drawbacks to using Indica strains of cannabis before bedtime. While Indica is recognized for its relaxing and sedative effects, improper use or overuse may result in unwanted side effects.

Dry mouth is a common issue experienced by people who use Indica before bedtime. Cannabis can dehydrate the mouth, making it difficult to sleep. Drinking fluids can alleviate this before and during use.

Dry eyes is another potential adverse side effect. Cannabis use can cause the eyes to become dry and red, impacting sleep quality. This can be mitigated by using eye moisturizing products or artificial tears.

Using Indica before bedtime can also result in dizziness, impaired coordination, and memory problems, which can be particularly dangerous for those engaged in activities that require focus and coordination, such as driving or operating machinery.

Additionally, Indica use can interfere with the normal sleep-wake cycle, resulting in feelings of fatigue and drowsiness the following day. This can negatively impact users with morning obligations, such as work.

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