What Are the Side Effects of CBD Sleep Gummies?

Direct Answer

For most adults, CBD sleep gummies cause nothing worse than next-morning drowsiness, dry mouth or a mild upset stomach, mostly at higher doses. The bigger watch-out is medication, since CBD changes how your liver clears some prescriptions, and gummies with L-tryptophan shouldn’t be mixed with antidepressants.

Start with what’s actually in the gummy, because side effects come from the ingredients, not from the word “sleep” on the label. CBD (cannabidiol, the non-intoxicating compound in hemp) has the deepest safety record. In trials of Epidiolex, the FDA-approved prescription form of CBD, the most common side effects were sleepiness, lower appetite, diarrhea and changes in liver enzymes, at 10 to 20 mg per kilogram of body weight a day. For a 150-pound adult that works out to roughly 700 to 1,400 mg daily, about 70 to 140 times the 10 mg of CBD in one of our CBD + CBN Sleep Gummies. CBN (cannabinol, a lesser-known cannabinoid that forms as THC ages) has much less research behind it. In a 2024 trial of 321 adults published in Experimental and Clinical Psychopharmacology, 20 mg of CBN taken with or without CBD didn’t raise next-day fatigue scores compared with placebo. Plenty of sleep gummies also contain melatonin, which Mayo Clinic lists as a common cause of headache, dizziness, nausea and daytime sleepiness. Ours have none.

New to sleep gummies? Take half a gummy 30 to 60 minutes before bed, then wait a full 90 minutes before you decide you need more. Most groggy mornings trace back to a second dose taken too soon. Run through this list before your first night. If you take a blood thinner like warfarin, seizure medication or anything with a grapefruit warning on the label, ask your pharmacist first, since CBD slows the same liver enzymes grapefruit does. If you take an antidepressant (SSRIs, MAOIs and tricyclics count), skip formulas with L-tryptophan; WebMD flags that pairing for serotonin syndrome, a rare but serious reaction. Don’t stack a sleep gummy with alcohol or a prescription sleep aid, because the sedation adds up. And if you’re pregnant or nursing, sit this one out. Our CBD + CBN gummies are THC-free, so there’s no high. A sleep gummy that does contain THC can add dry mouth, a faster heartbeat or a foggier morning, mostly at higher doses.

  • Degelis Pilla, CEO

    Degelis Pilla, CFA

    CEO and Co-Founder

    Degelis (“Dege,” pronounced “Dayj”) launched TribeTokes in 2017 after identifying a specific problem in the cannabis vaping market: most products were made with cutting agents and additives that had no place in a wellness brand. She built TribeTokes from zero into a multi-million dollar DTC brand with over 100,000 customers, a full cannabinoid product catalog, and a loyal wholesale retail network.

    Degelis is an active member of the Entrepreneurs’ Organization and a regular voice in both the cannabis and women-in-business spaces. She is a CFA charterholder (Chartered Financial Analyst), and holds her undergraduate business degree from the University of Virginia.
Shop CBD + CBN Sleep Gummies 10mg CBD + 20mg CBN per gummy. THC-free, no melatonin, third-party lab tested.
→
Compare CBD Gummies for Sleep Every CBD sleep gummy we make, each batch with a COA.
→
Related questions

Frequently asked questions

What Are the Side Effects of CBD Sleep Gummies?

For most adults, CBD sleep gummies cause nothing worse than next-morning drowsiness, dry mouth or a mild upset stomach, mostly at higher doses. The bigger watch-out is medication, since CBD changes how your liver clears some prescriptions, and gummies with L-tryptophan shouldn't be mixed with antidepressants.

Does CBN make you groggy in the morning?

CBN usually doesn't leave people groggy at the doses used in sleep gummies. In a 2024 trial of 321 adults, 20 mg of CBN didn't raise next-day fatigue compared with placebo. Morning fog tends to come from a dose that's too big or taken too late, and melatonin blends are another common cause. If you wake up foggy, drop to half a gummy and take it a little earlier.

Can you take CBD sleep gummies with antidepressants or other medications?

Sometimes, but check with your pharmacist first. CBD slows the liver enzymes that clear many prescriptions, including blood thinners and some seizure medications, so their levels in your blood can rise. Gummies with L-tryptophan add a second issue, since tryptophan plus an SSRI, MAOI or other antidepressant can contribute to serotonin syndrome. Our CBD + CBN Sleep Gummies contain 250 mg of L-tryptophan, so this applies to them.

What are the side effects of CBN?

CBN's reported side effects are usually light and mostly overlap with CBD's, such as sleepiness, dry mouth and an occasional upset stomach. Research is thin, though. Most human data comes from small sleep trials using about 20 to 30 mg, so long-term effects aren't well studied yet. CBN is considered only mildly intoxicating, and at gummy doses most people feel relaxed rather than high.

Are CBD sleep gummies safe to take every night?

For most healthy adults, nightly use at label doses appears to be well tolerated, though long-term data on CBN is limited. CBD isn't considered habit-forming, and the World Health Organization's 2018 review found no evidence of abuse or dependence potential. Take a night off now and then to check you still need it, and see your doctor if poor sleep lasts more than a few weeks.

For more detailed information, read CBD for Sleep.

This content is for informational purposes only and does not constitute medical advice. These statements have not been evaluated by the FDA. TribeTokes products are not intended to diagnose, treat, cure, or prevent any disease. Consult a healthcare professional before using cannabinoid products, especially if you take prescription medications.